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Company	Category	Region	Status	Sources	Links
SigOptAccess the open source version of SigOpt for intelligent experimentation	Vertical	San Francisco, CA, USA		Docs	Open homepage
Silentium	AI infra	Israel		Docs Gigasheet	Open homepage
Silico DataOur mission is to rethink how medicine is made	Vertical	San Jose, California, United States		Docs	Open homepage
Silimate	Vertical	San Francisco, CA, USA		Docs	Open homepage
SilkChartSilkChart analyzes sales calls and measures how well playbooks are executed. It proactively surfaces coaching opportunities to managers, and provides reps with actionable feedback to drive better conversations with clients and increase close rates.	Vertical	San Francisco, CA, USA; Remote		Docs	Open homepage
SilogyDevelop Chips Faster with Viv, an AI agent for digital design verification	Vertical	New York City, NY, USA; Remote		Docs	Open homepage
Silora R&D	AI infra	Israel		Docs Gigasheet	Open homepage
Siltech Network Solutions	AI infra	Israel		Docs Gigasheet	Open homepage
Silurian	Energy	Seattle, WA, USA		Docs	Open homepage
silverback.ai	Vertical	Israel		Docs Gigasheet	Open homepage
Silverlining Cloud Security	AI infra	Israel		Docs Gigasheet	Open homepage
Sim	Agents	San Francisco, CA, USA	5 open	Docs	Open homepage
Simbie AISimbie AI’s clinically-trained voice agents act as your 24/7 AI medical receptionist—handling scheduling, refills & intake with 60% cost savings. Loved by doctors & patients.	Vertical	New York City, NY, USA		Docs	Open homepage
SimCareAI Client simulations for better counselor training. Speak directly with avatars to practice counseling skills, explore different scenarios, and get instant feedback.	Vertical	New York City, NY, USA		Docs	Open homepage
SimicXBrowse hundreds of research-grounded trading alphas distilled from recent quantitative finance research. Filter by cross-section vs time-series, frequency, method, and asset class.	AI infra	Brentford, England, United Kingdom		Docs	Open homepage
Simlat Uas Training & Simulation	Robotics	Israel		Docs Gigasheet	Open homepage
Simone Veil Research Centre for Contemporary European Studies, Ben-Gurion University of the Negev	Vertical	Israel		Docs Gigasheet	Open homepage
Simple AI	Vertical	San Francisco, CA, USA		Docs	Open homepage
Simple Idea Ltd - Product Design & Development.	Other	Israel		Docs Gigasheet	Open homepage
Simplebu	Other	Israel		Docs Gigasheet	Open homepage
simplestoolbar.com	Other	Israel		Docs Gigasheet	Open homepage
Simplex	Agents	San Francisco, CA, USA		Docs	Open homepage
Simplex Digital Hotel Marketing Ltd.	Other	Israel		Docs Gigasheet	Open homepage
Simplex Mapping Solutions Ltd	Other	Israel		Docs Gigasheet	Open homepage

Staff list a company once its homepage loads and one to three sources back it up. Map pins use a sourced city or region — near that place or at the region centroid. Unknown location stays list-only. Founders, exit, and jobs stay omitted unless sourced. Founder photos stay omitted unless a sourced URL is listed — we never invent a face. We do not invent people, a street address, or size, price, or growth figures.